Marine Polyether Phycotoxin Palytoxin Induces Apoptotic Cell Death via Mcl-1 and Bcl-2 Downregulation

Palytoxin is considered one of the most potent biotoxins. As palytoxin-induced cancer cell death mechanisms remain to be elucidated, we investigated this effect on various leukemia and solid tumor cell lines at low picomolar concentrations. As palytoxin did not affect the viability of peripheral blo...

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Principais autores:	Jaemyun Kim, Seungwon Ji, Jin-Young Lee, Jean Lorquin, Barbora Orlikova-Boyer, Claudia Cerella, Aloran Mazumder, Florian Muller, Mario Dicato, Olivier Detournay, Marc Diederich
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-04-01
Serija:	Marine Drugs
Teme:	palytoxin cell death apoptosis Bcl-2 Mcl-1 leukemia
Online dostop:	https://www.mdpi.com/1660-3397/21/4/233
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