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A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells

Abstract Background Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancies. Mcl-1, another anti-apoptotic Bcl-2 family member, is recognized as...

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Principais autores: Tianming Zhao, Qiang He, Shurong Xie, Huien Zhan, Cheng Jiang, Shengbin Lin, Fangshu Liu, Cong Wang, Guo Chen, Hui Zeng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-01-01
Serier:Molecular Medicine
Fag:
Mcl-1 inhibitor
Bcl-2
Venetoclax
Apoptosis
AML
Online adgang:https://doi.org/10.1186/s10020-022-00565-7
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