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Developing the protein quality control system in Streptomyces for selective translation of ultra-long full-length polyketide synthase mRNAs to enhance biosynthesis efficiency

Genes that encode type I polyketide synthases (PKSs), which synthesize an array of invaluable drugs, typically exceed 10 kilobases in length. Truncated messenger RNAs (mRNAs) have been demonstrated to constitute the majority of PKS mRNAs; However, a method for the selective translation of full-lengt...

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Main Authors: Chanjuan Jiang, Kexin Hao, Shaoqian Wang, Ruofei Guo, Xiaochen Li, Lin Lv, Ji Luan, Hailong Wang
Format: Artigo
Language:Inglês
Published: KeAi Communications Co., Ltd. 2026-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Polyketide synthase
Streptomyces
Translational regulation
Protein quality control
Truncated mRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25001668
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