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Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer therapy by targeting crucial coinhibitory pathways. Pathways involving PD‐1/PD‐L1 and CTLA‐4 are essential for immune homeostasis but are frequently exploited by tumors to evade immune surveillance. ICIs block these interactions, u...

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Principais autores: Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-06-01
Serier:MedComm
Fag:
immune checkpoints
immune combination therapies
immune escape
immune resistance
immunotherapy
tumor microenvironment
Online adgang:https://doi.org/10.1002/mco2.70771
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