Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina

Abstract Background Tetrahydrobiopterin (BH4) is an essential cofactor in multiple metabolic processes and plays an essential role in maintaining the inflammatory and neurovascular homeostasis. In this study, we have investigated the deleterious effects of BH4 deficiency on retinal vasculature durin...

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Bibliografische Detailangaben

Hauptverfasser:	José Carlos Rivera, Baraa Noueihed, Ankush Madaan, Isabelle Lahaie, Jingyi Pan, Jaques Belik, Sylvain Chemtob
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2017-09-01
Schriftenreihe:	Journal of Neuroinflammation
Schlagworte:	Tetrahydrobiopterin BH4 Microvascular degeneration Thrombospondin-1 Inflammation Microglia
Online-Zugang:	http://link.springer.com/article/10.1186/s12974-017-0955-x
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