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Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina

Abstract Background Tetrahydrobiopterin (BH4) is an essential cofactor in multiple metabolic processes and plays an essential role in maintaining the inflammatory and neurovascular homeostasis. In this study, we have investigated the deleterious effects of BH4 deficiency on retinal vasculature durin...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: José Carlos Rivera, Baraa Noueihed, Ankush Madaan, Isabelle Lahaie, Jingyi Pan, Jaques Belik, Sylvain Chemtob
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2017-09-01
Rangatū:Journal of Neuroinflammation
Ngā marau:
Tetrahydrobiopterin
BH4
Microvascular degeneration
Thrombospondin-1
Inflammation
Microglia
Urunga tuihono:http://link.springer.com/article/10.1186/s12974-017-0955-x
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