Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery

The growing demand for viral vectors as nanoscale therapeutic agents in gene therapy necessitates efficient and scalable purification methods. This study examined the role of nanoscale biomaterials in optimizing viral vector clarification through a model system mimicking real AAV2 crude harvest mate...

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Autori principali:	Mara Leach, Kearstin Edmonds, Emily Ingram, Rebecca Dutch, Ranil Wickramasinghe, Malgorzata Chwatko, Dibakar Bhattacharyya
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-02-01
Serie:	Nanomaterials
Soggetti:	AAV2 silica nanoparticles membrane filtration fouling models downstream bioprocessing gene therapy
Accesso online:	https://www.mdpi.com/2079-4991/15/4/310
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