Quantitative Analysis of Protein Fouling in Virus Removal Filtration Membranes Through Electron Tomography

Protein fouling can significantly reduce the filtrate flux, capacity, and virus retention during processing of plasma- or mammalian cell-derived biopharmaceuticals through virus removal filters. We use focused ion beam (FIB) milling and scanning electron microscopy (SEM) to directly evaluate changes...

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Principais autores:	Mohammad A. Afzal, Kaitlyn P. Brickey, Enrique D. Gomez, Andrew L. Zydney
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-12-01
coleção:	Membranes
Assuntos:	virus filtration protein fouling pore morphology electron tomography pore size distribution
Acesso em linha:	https://www.mdpi.com/2077-0375/15/12/369
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