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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism

Abstract Objectives Lung cancer is a leading cause of global cancer mortality. Clinical observations reveal that histological transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is accompanied by mutations in TP53 and RB1. By applying gradually increasing cisplati...

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Autori principali: Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer 2025-03-01
Serie:Journal of Cancer Research and Clinical Oncology
Soggetti:
NSCLC
TP53
RB1
Phenotype
Glucose metabolism
Fatty acid metabolism
Accesso online:https://doi.org/10.1007/s00432-025-06164-3
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