Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism

Abstract Objectives Lung cancer is a leading cause of global cancer mortality. Clinical observations reveal that histological transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is accompanied by mutations in TP53 and RB1. By applying gradually increasing cisplati...

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Автори:	Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Springer 2025-03-01
Серія:	Journal of Cancer Research and Clinical Oncology
Предмети:	NSCLC TP53 RB1 Phenotype Glucose metabolism Fatty acid metabolism
Онлайн доступ:	https://doi.org/10.1007/s00432-025-06164-3
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