Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives
Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constan...
Furkejuvvon:
| Váldodahkkit: | , , , |
|---|---|
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
MDPI AG
2017-11-01
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| Ráidu: | Scientia Pharmaceutica |
| Fáttát: | |
| Liŋkkat: | https://www.mdpi.com/2218-0532/85/4/37 |
| Fáddágilkorat: |
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