Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity

Caffeine is the most widely consumed psychoactive substance globally, yet its peripheral physiological effects remain incompletely understood. Leveraging comprehensive data from 13,091 blood donors in the REDS RBC-Omics study, we identify caffeine as a significant modulator of red blood cell (RBC)...

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Principais autores:	Monika Dzieciatkowska, Ariel Hay, Aaron Issaian, Gregory R. Keele, Shaun Bevers, Travis Nemkov, Julie A. Reisz, Mark Maslanka, Daniel Stephenson, Amy L. Moore, Xutao Deng, Mars Stone, Kirk C. Hansen, Steve Kleinman, Philip J. Norris, Michael P. Busch, Grier P. Page, Nareg Roubinian, Yang Xia, James C. Zimring, Angelo D’Alessandro
Formato:	Artigo
Idioma:	Inglês
Publicado:	Ferrata Storti Foundation 2025-09-01
Series:	Haematologica
Acceso en liña:	https://haematologica.org/article/view/12261
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