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Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

The link between changes in astrocyte function and the pathological progression of Alzheimer's disease (AD) has attracted considerable attention. Interestingly, activated astrocytes in AD show abnormalities in their lipid content and metabolism. In particular, the expression of apolipoprotein E (Apo...

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Váldodahkkit: Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2024-03-01
Ráidu:Journal of Lipid Research
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Liŋkkat:http://www.sciencedirect.com/science/article/pii/S0022227524000154
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