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M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

<p>Abstract</p> <p>Background</p> <p>HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.</p> <p>Findings</p> <p>To address this problem, here, we report...

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Main Authors: Selhorst Philippe, Grupping Katrijn, Tong Tommy, Crooks Ema T, Martin Loïc, Vanham Guido, Binley James M, Ariën Kevin K
Format: Artigo
Language:Inglês
Published: BMC 2013-02-01
Series:Retrovirology
Subjects:
HIV
Entry
CD4 binding site
gp120
Shedding
Inhibition
Online Access:http://www.retrovirology.com/content/10/1/12
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