Design of a Bispecific HIV Entry Inhibitor Targeting the Cell Receptor CD4 and Viral Fusion Protein Gp41

Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a very potent short-peptide–based HIV fusion inhibit...

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Principais autores:	Hongxia Yan, Tong Wu, Yue Chen, Hongliang Jin, Li Li, Yuanmei Zhu, Huihui Chong, Yuxian He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-05-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	HIV entry bispecific inhibitor fusion inhibitors CD4 ibalizumab
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.916487/full
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