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Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

The pathological prion protein, PrPSc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrPSc aggregates of mouse-adapted prion strains. We showed that small PrPSc aggregates, previously...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Takashi Yokoyama, Shirou Mohri, Morikazu Imamura, Yoshifumi Iwamaru, Kentaro Masujin, Kazuo Kasai
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2013-02-01
Schriftenreihe:Pathogens
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Online-Zugang:http://www.mdpi.com/2076-0817/2/1/92
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