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Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPSc

Abstract Transmissible spongiform encephalopathies, also known as prion diseases, are a group of fatal neurodegenerative disorders affecting both humans and animals. The central pathogenic event in prion disease is the misfolding of normal prion protein (PrPC) into the pathogenic conformer, PrPSc, w...

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Main Authors: Fei Wang, Xinhe Wang, Romany Abskharon, Jiyan Ma
Format: Artigo
Language:Inglês
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
Prion disease
Prion
PrPSc
Recombinant prion
Proteinase K-resistant
Prion infectivity
Online Access:http://link.springer.com/article/10.1186/s40478-018-0534-0
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