Target-based drug discovery: Applications of fluorescence techniques in high throughput and fragment-based screening

Target-based discovery of first-in-class therapeutics demands an in-depth understanding of the molecular mechanisms underlying human diseases. Precise measurements of cellular and biochemical activities are critical to gain mechanistic knowledge of biomolecules and their altered function in disease...

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Bibliographic Details

Main Authors:	Vikrant Kumar, Puneeth Kumar Chunchagatta Lakshman, Thazhe Kootteri Prasad, Kavyashree Manjunath, Sneha Bairy, Akshaya S. Vasu, B. Ganavi, Subbarao Jasti, Neelagandan Kamariah
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2024-01-01
Series:	Heliyon
Subjects:	Target-based drug discovery High throughput screening Fragment based ligand discovery Fluorescence-based assays Fluorescence polarization Förster resonance energy transfer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844023110723
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