Astroglia proliferate upon the biogenesis of tunneling nanotubes via α-synuclein dependent transient nuclear translocation of focal adhesion kinase

Summary: Astroglia play crucial neuroprotective roles by internalizing pathogenic aggregates and facilitating their degradation. Here, we show that α-SYN protofibril-induced organelle toxicities and reactive oxygen species (ROS) cause premature cellular senescence in astrocytes and astrocyte-derived...

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Detalhes bibliográficos

Principais autores:	Abinaya Raghavan, Rachana Kashyap, P. Sreedevi, Sneha Jos, Suchana Chatterjee, Ann Alex, Michelle Ninochka D’Souza, Mridhula Giridharan, Ravi Muddashetty, Ravi Manjithaya, Sivaraman Padavattan, Sangeeta Nath
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-08-01
coleção:	iScience
Assuntos:	Biological sciences Molecular biology Neuroscience Cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004224017905
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