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Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

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Principais autores: Tam N.T. Nguyen, Sha Sha, Moo Sun Hong, Andrew J. Maloney, Paul W. Barone, Caleb Neufeld, Jacqueline Wolfrum, Stacy L. Springs, Anthony J. Sinskey, Richard D. Braatz
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Assuntos:
gene therapy
gene-therapy manufacturing
viral vector
transfection
mechanistic modeling
mechanistic understanding
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050121000723
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