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Evolutionary relaxation and functional change of INSL3 and RXFP2 may underlie natural cryptorchidism in mammals

Abstract Cryptorchidism is a common congenital abnormality that increases infertility and testicular cancer risk in adulthood. However, a few mammals exhibit naturally undescended testes while maintaining normal reproduction. The mechanisms underlying this natural cryptorchidism remain unclear. Here...

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Principais autores: Yu Zheng, Simin Chai, Cuijuan Zhong, Yixuan Sun, Shixia Xu, Wenhua Ren, Guang Yang
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Nature 2025-11-01
סדרה:EMBO Reports
נושאים:
Cryptorchidism
INSL3
Gubernaculum Development
Inflammation in Cryptorchid Testes
Evolutionary Relaxation
גישה מקוונת:https://doi.org/10.1038/s44319-025-00636-w
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