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Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases

Asynchronous Ca2+ release promotes non-homogeneous myofilament activation, leading to mechanical dysfunction, as well as initiation of propagated calcium waves and arrhythmias. Recent advances in microscopy techniques have allowed for optical recordings of local Ca2+ fluxes and action potentials fro...

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Principais autores: Marina Scardigli, Cecilia Ferrantini, Claudia Crocini, Francesco S. Pavone, Leonardo Sacconi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-10-01
Serier:Frontiers in Physiology
Fag:
t-tubule
excitation-contraction coupling
calcium imaging
voltage imaging
microscopy
Online adgang:https://www.frontiersin.org/article/10.3389/fphys.2018.01474/full
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