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Avidity of autoantibodies against type I interferons as a factor associated with neurological complications in severe COVID-19

BackgroundAutoantibodies against type I interferons (IFNs), particularly IFN-α2 and IFN-ω, are a recognized risk factor for severe COVID-19. Their functional characterization has largely focused on their neutralizing capacity. However, antibody binding avidity represents a distinct biophysical param...

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Hoofdauteurs: Mario Framil, Lydia García-Serrano, Adrián García-García, Inés Caballero-Segarra, Jose Luis Gomez-Vazquez, Arnau Antolí, Xavier Solanich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2026-07-01
Reeks:Frontiers in Immunology
Onderwerpen:
antibody avidity
anti-type I IFN autoantibodies
COVID-19
IFN-α
IFN-ω
neurological complications
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1893615/full
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