Avidity of autoantibodies against type I interferons as a factor associated with neurological complications in severe COVID-19

BackgroundAutoantibodies against type I interferons (IFNs), particularly IFN-α2 and IFN-ω, are a recognized risk factor for severe COVID-19. Their functional characterization has largely focused on their neutralizing capacity. However, antibody binding avidity represents a distinct biophysical param...

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Główni autorzy:	Mario Framil, Lydia García-Serrano, Adrián García-García, Inés Caballero-Segarra, Jose Luis Gomez-Vazquez, Arnau Antolí, Xavier Solanich
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2026-07-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	antibody avidity anti-type I IFN autoantibodies COVID-19 IFN-α IFN-ω neurological complications
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1893615/full
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