Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues

ABSTRACT Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied t...

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Bibliografische Detailangaben

Hauptverfasser:	Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2023-10-01
Schriftenreihe:	mSphere
Schlagworte:	gammaherpesvirus lytic replication uracil-DNA glycosylase viral DNA polymerase viral DNA polymerase processivity factor viral replication compartment
Online-Zugang:	https://journals.asm.org/doi/10.1128/msphere.00278-23
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