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SIRT1-mediated deacetylation of DRP1 suppresses excessive mitophagy and ameliorates pediatric functional dyspepsia

Abstract Functional dyspepsia (FD) is a prevalent gastrointestinal disorder in children, but its underlying molecular mechanisms remain poorly understood. Mitochondrial dysfunction and excessive mitophagy have been implicated in FD, but the underlying mechanisms remain poorly understood. This study...

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Principais autores: Shuan Yin, Dongdong Dai, Gaoyan Wang, Shaomei Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:BMC Immunology
Fag:
SIRT1
Functional dyspepsia
DRP1
Deacetylation
Mitophagy
Online adgang:https://doi.org/10.1186/s12865-026-00842-8
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