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AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells

Abstract Hematopoietic stem and progenitor cells (HSPCs) polarize in contact with the bone marrow stromal cells constituting their niche. Given the role of cell polarity in protection against tumorigenesis and the importance of the niche in the progression of acute myeloid leukemias (AMLs), we inves...

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Hoofdauteurs: Khansa Saadallah, Benoît Vianay, Louise Bonnemay, Hélène Pasquer, Lois Kelly, Stéphanie Mathis, Cécile Culeux, Raphael Marie, Paul Arthur Meslin, Sofiane Fodil, Paul Chaintreuil, Emeline Kerreneur, Arnaud Jacquel, Emmanuel Raffoux, Rémy Nizard, Camille Lobry, Laurent Blanchoin, Lina Benajiba, Manuel Théry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Nature 2025-06-01
Reeks:EMBO Reports
Onderwerpen:
Acute Myeloid Leukemia (AML)
Hematopoietic Stem and Progenitor Cells (HSPCs)
Artificial Niche
Microwell
Bone-marrow-on-a-Chip (BMoC)
Online toegang:https://doi.org/10.1038/s44319-025-00466-w
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