CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters
Abstract Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets have been proposed as an attractive...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2018-10-01
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| Col·lecció: | Genome Biology |
| Matèries: | |
| Accés en línia: | http://link.springer.com/article/10.1186/s13059-018-1534-x |
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