Rad5 participates in lesion bypass through its Rev1-binding and ubiquitin ligase domains, but not through its helicase function

DNA Damage Tolerance (DDT) functions to bypass replication-blocking lesions and is divided into two distinct pathways: error-prone Translesion Synthesis (TLS) and error-free Damage Avoidance (DA). Rad5 is a multifunctional protein that is involved in these DDT processes. Saccharomyces cerevisiae Rad...

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Principais autores:	Katarzyna H. Masłowska, Vincent Pagès
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Molecular Biosciences
Assuntos:	DNA damage DNA damage response (DDR) translesion synthesis (TLS) homologous recombination (HR) Rad5 (HTLF) Saccharomyces cerevisiae
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1062027/full
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