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The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels

Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin) is a stable prostacyclin analogue with potent vasodilatory and anti-proliferative activity, approved by the FDA and WHO as a treatment for PAH...

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Bibliografiske detaljer
Principais autores: Kevin P. Cunningham, Lucie H. Clapp, Alistair Mathie, Emma L. Veale
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-06-01
Serier:Frontiers in Pharmacology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.705421/full
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