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Targeting XBP1 mRNA splicing sensitizes glioblastoma to chemotherapy

Abstract Glioblastoma (GBM) is the most frequent and deadly primary brain tumor in adults. Temozolomide (TMZ) is the standard systemic therapy in GBM but has limited and restricted efficacy. Better treatments are urgently needed. The role of endoplasmic reticulum stress (ER stress) is increasingly d...

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Principais autores: Amiee Dowdell, Mark Marsland, Sam Faulkner, Craig Gedye, James Lynam, Cassandra P. Griffin, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2023-05-01
Serier:FASEB BioAdvances
Fag:
cancer biomarkers
glioblastoma
therapeutic targets
XBP1s
Online adgang:https://doi.org/10.1096/fba.2022-00141
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