Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes

Osteoarthritis (OA) is the most common chronic disease characterized by a loss of chondrocytes and the degeneration of cartilage. Inflammation plays an important role in the pathogenesis and progression of OA via the activation of the endoplasmic reticulum (ER) stress signaling pathway. In this stud...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kunpeng Qin, Hao Tang, Yi Ren, Di Yang, Yetian Li, Wei Huang, Yunfeng Wu, Zongsheng Yin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-08-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	melatonin osteoarthritis endoplasmic reticulum stress apoptosis IRE1α > XBP1S > CHOP
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2022.940629/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!