Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IDD) is a prevalent condition contributing to back pain and disability. Leukemia inhibitory factor (LIF) has emerged as a protective gene in IDD, prompting further investigation into its role and mechanisms. This study employs bioinformatics analysis combin...

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Autori principali:	Zhen Wang, Jichen Liu, Haishan Xu, Yanhua Sun, Shaowei Xu, Xijing He
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-11-01
Serie:	Journal of Orthopaedic Surgery and Research
Soggetti:	Leukemia inhibitory factor Intervertebral disc degeneration Intercellular adhesion molecule-1 Nucleus pulposus Pyroptosis
Accesso online:	https://doi.org/10.1186/s13018-025-06494-5
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