Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

A complex assembly of lipids including fatty acids, cholesterol, and ceramides is vital to the integrity of the mammalian epidermal barrier. The formation of this barrier requires oxidation of the substrate fatty acid, linoleic acid (LA), which is initiated by the enzyme 12R-lipoxygenase (LOX). In t...

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主要な著者:	Victoria J. Tyrrell, Faraz Ali, William E. Boeglin, Robert Andrews, James Burston, James C. Birchall, John R. Ingram, Robert C. Murphy, Vincent Piguet, Alan R. Brash, Valerie B. O'Donnell, Christopher P. Thomas
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2021-01-01
シリーズ:	Journal of Lipid Research
主題:	ceramides clinical lipidology epidermis lipid metabolism in the skin lipids/oxidation lipoxygenase
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0022227521000766
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