Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

A complex assembly of lipids including fatty acids, cholesterol, and ceramides is vital to the integrity of the mammalian epidermal barrier. The formation of this barrier requires oxidation of the substrate fatty acid, linoleic acid (LA), which is initiated by the enzyme 12R-lipoxygenase (LOX). In t...

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Bibliografische Detailangaben

Hauptverfasser:	Victoria J. Tyrrell, Faraz Ali, William E. Boeglin, Robert Andrews, James Burston, James C. Birchall, John R. Ingram, Robert C. Murphy, Vincent Piguet, Alan R. Brash, Valerie B. O'Donnell, Christopher P. Thomas
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-01-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	ceramides clinical lipidology epidermis lipid metabolism in the skin lipids/oxidation lipoxygenase
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227521000766
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