Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels

BackgroundFibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the re...

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Autors principals:	Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-01-01
Col·lecció:	Frontiers in Cardiovascular Medicine
Matèries:	fibroblasts ischemic heart disease cardiac fibrosis single nuclei RNA sequencing diagnostic model
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1460813/full
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