Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels

BackgroundFibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the re...

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Autori principali:	Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-01-01
Serie:	Frontiers in Cardiovascular Medicine
Soggetti:	fibroblasts ischemic heart disease cardiac fibrosis single nuclei RNA sequencing diagnostic model
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1460813/full
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