A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary cerebral small vessel disease (SVD), currently lacks disease-modifying treatments. Adrenomedullin (AM), a vasoactive peptide with angiogenic, vasodilat...

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Main Authors:	Kazuo Washida, Satoshi Saito, Tomotaka Tanaka, Yuriko Nakaoku, Hiroyuki Ishiyama, Soichiro Abe, Takehito Kuroda, Shinsaku Nakazawa, Chikage Kakuta, Katsuhiro Omae, Kenta Tanaka, Manabu Minami, Yoshiaki Morita, Tetsuya Fukuda, Akihiro Shindo, Takakuni Maki, Kazuo Kitamura, Hidekazu Tomimoto, Toshihiko Aso, Masafumi Ihara
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2024-01-01
Series:	Cerebral Circulation - Cognition and Behavior
Subjects:	Adrenomedullin Arterial spin labeling Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Cerebral blood flow Clinical trial
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666245024000126
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