Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors

Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling. Their upregulation results in various disease conditions, for example, inflammation, hypoxia and cancer. Therefore, efforts have been made to synth...

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Библиографические подробности

Главные авторы:	Sidra Hassan, Pervaiz Ali Channar, Fayaz Ali Larik, Aamer Saeed, Hamid Saeed Shah, Joanna Lecka, Jean Sévigny, Jamshed Iqbal
Формат:	Artigo
Язык:	Inglês
Опубликовано:	The Royal Society 2018-01-01
Серии:	Royal Society Open Science
Предметы:	ecto-5′-nucleotidase thiazole schiff base azomethines
Online-ссылка:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180837
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