Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors

Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling. Their upregulation results in various disease conditions, for example, inflammation, hypoxia and cancer. Therefore, efforts have been made to synth...

Descrición completa

Detalles Bibliográficos

Principais autores:	Sidra Hassan, Pervaiz Ali Channar, Fayaz Ali Larik, Aamer Saeed, Hamid Saeed Shah, Joanna Lecka, Jean Sévigny, Jamshed Iqbal
Formato:	Artigo
Idioma:	Inglês
Publicado:	The Royal Society 2018-01-01
Series:	Royal Society Open Science
Assuntos:	ecto-5′-nucleotidase thiazole schiff base azomethines
Acceso en liña:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180837
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!