Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats

The dysfunction of descending noradrenergic (NAergic) modulation in second-order neurons has long been observed in neuropathic pain. In clinical practice, antidepressants that increase noradrenaline levels in the synaptic cleft are used as first-line agents, although adequate analgesia has not been...

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Autores principales:	Yoshinori Hayashi, Jo Otsuji, Eri Oshima, Suzuro Hitomi, Junjun Ni, Kentaro Urata, Ikuko Shibuta, Koichi Iwata, Masamichi Shinoda
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-07-01
Colección:	Brain, Behavior, & Immunity - Health
Materias:	Exosomes Interferon-γ Locus coeruleus Major histocompatibility complex I Mechanical allodynia Microglia
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2666354623000364
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