Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.

Deficiency in DNA ligase I, encoded by CDC9 in budding yeast, leads to the accumulation of unligated Okazaki fragments and triggers PCNA ubiquitination at a non-canonical lysine residue. This signal is crucial to activate the S phase checkpoint, which promotes cell cycle delay. We report here that a...

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Principais autores:	Hai Dang Nguyen, Jordan Becker, Yee Mon Thu, Michael Costanzo, Elizabeth N Koch, Stephanie Smith, Kyungjae Myung, Chad L Myers, Charles Boone, Anja-Katrin Bielinsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3688925?pdf=render
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