Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

Efficient DNA replication is crucial for genome stability. Here, Thakar et al. report that accumulation of lagging strand ssDNA gaps during replication interferes with nucleosome assembly and drives replication fork degradation in BRCA-deficient cells.

מידע ביבליוגרפי

Principais autores:	Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2022-09-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-022-33028-y
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