क्यूआर कोड

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase promotes stalled fork recovery and limits fork hyper-...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Portfolio 2021-11-01
श्रृंखला:Nature Communications
ऑनलाइन पहुंच:https://doi.org/10.1038/s41467-021-26811-w
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