Evolutionary conservation of Zinc-Activated Channel (ZAC) functionality in mammals: a range of mammalian ZACs assemble into cell surface-expressed functional receptors

In contrast to the other pentameric ligand-gated ion channels in the Cys-loop receptor superfamily, the ZACN gene encoding for the Zinc-Activated Channel (ZAC) is exclusively found in the mammalian genome. Human ZAC assembles into homomeric cation-selective channels gated by Zn2+, Cu2+ and H+, but t...

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Autor principal:	Anders A. Jensen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-09-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	pentameric ligand-gated ion channel (pLGIC) Zinc-Activated Channel (ZAC) two-electrode voltage-clamp electrophysiology (TEVC) mammalian evolutionary conservation zinc
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1265429/full
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