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Turnover of protein phosphorylation evolving under stabilizing selection

Most proteins are regulated by posttranslational modifications and changes in these modifications contribute to evolutionary changes as well as to human diseases. Phosphorylation of serines, threonines and tyrosines are the most common modifications identified to date in eukaryotic proteomes. While...

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Principais autores: Christian R Landry, Luca eFreschi, Taraneh eZarin, Alan eMoses
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-07-01
coleção:Frontiers in Genetics
Assuntos:
Protein phosphorylation
Evolution, Molecular
Stabilizing selection
phorphorylation cluster
protein regulation
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00245/full
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