Aspirin‐Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis

Abstract Aspirin, also named acetylsalicylate, can directly acetylate the side‐chain of lysine in protein, which leads to the possibility of unexplained drug effects. Here, the study used isotopic‐labeling aspirin‐d3 with mass spectrometry analysis to discover that aspirin directly acetylates 10 HDA...

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Detalles Bibliográficos

Principais autores:	Liangguo Xie, Chaoqun Li, Chao Wang, Zhen Wu, Changchun Wang, Chunyu Chen, Xiaojian Chen, Dejian Zhou, Qiang Zhou, Ping Lu, Chen Ding, Chen‐Ying Liu, Jinzhong Lin, Xumin Zhang, Xiaofei Yu, Wei Yu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-05-01
Series:	Advanced Science
Assuntos:	acetylation modification apoptosis aspirin intestinal immune homeostasis SIRT1 deacetylase
Acceso en liña:	https://doi.org/10.1002/advs.202306378
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