Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP⁺-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent reduction of αKG to the oncometabolit...

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Bibliographic Details

Main Authors:	Joi Weeks, Alexandra I. Strom, Vinnie Widjaja, Sati Alexander, Dahra K. Pucher, Christal D. Sohl
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2021-05-01
Series:	Biomolecules
Subjects:	acetylation IDH1 kinetics post-translational modification
Online Access:	https://www.mdpi.com/2218-273X/11/5/740
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