Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics
Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP<sup>+</sup>-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent reduction of αKG to the oncometabolit...
I tiakina i:
| Ngā kaituhi matua: | , , , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
MDPI AG
2021-05-01
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| Rangatū: | Biomolecules |
| Ngā marau: | |
| Urunga tuihono: | https://www.mdpi.com/2218-273X/11/5/740 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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