Pharmacological reversion of sphingomyelin‐induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

Abstract Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a key modulator of the dendritic spine actin cytosk...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe‐Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman, Maria D Ledesma
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer Nature 2014-01-01
Цуврал:	EMBO Molecular Medicine
Нөхцлүүд:	dexamethasone Niemann Pick RhoA sphingomyelin
Онлайн хандалт:	https://doi.org/10.1002/emmm.201302649
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!